Life extension by 60% is possible by deleting specific genes

ByNew 1lluminati

The technique of 'immortality and death' that appears in science fiction is also very attractive for people in the real world,Research to realize thisIt is done. Meanwhile, the researchers announced that they succeeded in extending the life span of the cells by about 60% by deleting specific genes.

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging: Cell Metabolism
http://www.cell.com/cell-metabolism/abstract/S1550-4131(15)00465-9

Deleting genes could boost lifespan by 60 per cent, say scientists - Telegraph
http://www.telegraph.co.uk/news/science/science-news/11925154/Deleting-genes-could-boost-lifespan-by-60-per-cent-say-scientists.html

Institution for independently conducting research on America's first aging "The Buck Institute for Research on Aging"Washington University announced that it succeeded in extending the life span of yeast cells by deleting specific genes.

"Specific gene" refers to 238 kinds of genes, which seems to be present in many mammalian genes including humans. In addition, researchers believe that it is possible to dramatically increase the life span of organisms by deleting these genes in the living body.

ByStuart Caie

"This research focuses on the connection between aging and genetic information and what is" aging "," said Dr. Brian Kennedy, the primary author of the paper. Dr. Kennedy said, "About half of the genes related to aging that we found are also present in mammals.Theoretically, these genes are the targets for treatment to extend lifespan, and we What I have to do now is to unravel which genes have a strong influence on aging, "he says about future goals.

In the research done by Dr. Kennedy, we measure the lifespan of a cell, that is, "the number of divisions of a cell" in order to conclude which gene is the cause of aging. The number of cell divisions is finite and called "replicative lifespan" rather than infinite, and by using budding yeast, which is easy to investigate this replicative lifespan, "replication life changes when any gene is deleted That's why I studied. In the survey, we were deleting 4698 kinds of genes one by one and measuring the replicative lifetime by deleting which gene was deleted.

ByZappys Technology Solutions

As a result of the research, it was discovered that 238 kinds of genes possess some relationship with replicative lifespan. And, among them, it has been clarified that the gene called "LOS 1", when deleted, extends the life span of the cell by about 60%. "LOS 1" seems to be deeply involved in genetic factors related to "limiting calorie by fasting" and "extending life span", so it seems to be similar to the retardation effect of aging caused by fasting by losing "LOS 1" It became clear that a phenomenon occurred.

Dr. Mark McCormick, coauthor of the article, said, "The most wonderful achievement in our research is that yeasts have found that yeasts increase their longevity by about 60% due to single gene deletion," I will.

Relationship between "aging" and "fasting" has been drawing attention for a long time, but in June 2015 Mr. Balter Longo of the University of Southern California said, "It is possible that delaying" old "with periodic low calorie consumption Possible research results "has been announced. By continuing a low-calorie diet (FMD) that imitated fasting, it decreased the IGF-I value of the hormone required for growth, which would lead to prevention of aging. It is clear that FMD cuts individual calorie intake by 34-54% from normal, not only delaying aging but also reducing the risk of developing heart disease and cancer.

It turned out that it is possible to delay "old" with periodic low calorie diet ingestion - GIGAZINE


What was revealed this time was that "the replication lifespan of a cell grows by deleting a specific gene", but it is unknown whether these genes work in exactly the same way in mammals or human beings Place. Nevertheless, there must be new clues to realize elderly immortality and longevity that can be said to be human dreams.